USE OF GLUCOCORTICOSTEROIDS IN PEDIATRIC PRACTICE
Keywords:
Keywords: pediatric practice, glucocorticoid receptor, transcription protein, transcription factorsAbstract
Soft dosage forms for external use (ointments, creams, gels, emulsions,
liniments, pastes) of anti-allergic action were studied according to regulatory
documentation and electronic resources in the field of health care. The possibilities of
their application in pediatric practice are investigated. Data on contraindications,
limitations and precautions according to the age of children are presented. The results
of the review are presented in the form of 4 tables containing information on trade and
nonproprietary (INN) names of medicinal products, pharmacological groups and age
restrictions. Nosebleeds are common not only in adults but also in children. The most
common causes of nasal bleeding in children are acute respiratory diseases and trauma.
The aim of the study was to investigate the nature of microflora isolated from the nose
in children with recurrent nosebleeds. Staphylococcus aureus was found to be the most
frequently isolated microflora in children of this clinical group. The author suggests
that the cause of recurrent nosebleeds may be stimulation of angiogenesis in the nasal
mucosa by carrying pathogenic microflora. NLRs are a consequence of the same
mechanisms that determine the activity of GCS. Upon interaction with the cell, GCS
diffuse or are transported into the cytoplasm where they interact with the type II
glucocorticoid receptor, which in the inactive state is bound to heat shock proteins
(HSPs) with molecular masses of 90 and 70Da. heat shock proteins (HSPs) with
molecular masses of 90 and 70 kDa.BTSPs contribute, on the one hand, to the
maintenance of the receptor's inactive state of the receptor in the absence of GCS, on
the other hand - to maintain its high affinity. After GCS is bound to the receptor, BTSH
is detached and the GCS-receptor complex migrates to the nucleus of the cell where it
interacts with the receptor. the cell nucleus, where it interacts with DNA regions
located in the promoter fragment of the steroid-responsive gene, the so-called
glucocorticoid response elements (GRE).
response element (GRE).
References
REFERENCES
Saodat, A., Vohid, A., Ravshan, N., & Shamshod, A. (2020). MRI study in patients
with idiopathic cokearthrosis of the hip joint. International Journal of Psychosocial
Rehabilitation, 24(2), 410-415.
Axmedov, S. J. (2023). EFFECTS OF THE DRUG MILDRONATE. Innovative
Development in Educational Activities, 2(20), 40-59.
Уроков, Ш. Т., & Хамроев, Х. Н. (2019). Influe of diffusion diseases of the liver
on the current and forecfst of obstructive jaundice. Тиббиётда янги кун, 1, 30.
TESHAEV, S. J., TUHSANOVA, N. E., & HAMRAEV, K. N. (2020). Influence
of environmental factors on the morphometric parameters of the small intestine of
rats in postnatal ontogenesis. International Journal of Pharmaceutical Research
(09752366), 12(3).
Хамроев, Х. Н. (2022). Toxic liver damage in acute phase of ethanol intoxication
and its experimental correction with chelate zinc compound. European journal of
modern medicine and practice, 2, 2.
Gafurovna, A. N., Xalimovich, M. N., & Komilovich, E. B. Z. (2023).
KLIMAKTERIK YOSHDAGI AYOLLARDA ARTERIAL
GIPERTENZIYANING KECHISHI. ОБРАЗОВАНИЕ НАУКА И
ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 23(6), 26-31.
Komilovich, E. B. Z. (2023). Coronary Artery Disease. EUROPEAN JOURNAL OF
MODERN MEDICINE AND PRACTICE, 3(12), 81-87.
Эргашов, Б. К. (2023). Артериальная Гипертония: Современный Взгляд На
Проблему. Research Journal of Trauma and Disability Studies, 2(11), 250-261.
ASHUROVA, N. G., MAVLONOV, N. X., & ERGASHOV, B. Z. K. БИОЛОГИЯ
И ИНТЕГРАТИВНАЯ МЕДИЦИНА. БИОЛОГИЯ, (4), 92-101.
Jamshidovich, A. S. (2023). ASCORBIC ACID: ITS ROLE IN IMMUNE
SYSTEM, CHRONIC INFLAMMATION DISEASES AND ON THE
ANTIOXIDANT EFFECTS. EUROPEAN JOURNAL OF MODERN MEDICINE
AND PRACTICE, 3(11), 57-60.
Jamshidovich, A. S. (2023). THE ROLE OF THIOTRIAZOLINE IN THE
ORGANISM. Ta'lim innovatsiyasi va integratsiyasi, 9(5), 152-155.
Jamshidovich, A. S. (2023). HEPTRAL IS USED IN LIVER
DISEASES. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В
МИРЕ, 35(3), 76-78.
Jamshidovich, A. S. (2023). EFFECT OF TIVORTIN ON CARDIOMYOCYTE
CELLS AND ITS ROLE IN MYOCARDIAL INFARCTION. Gospodarka i
Innowacje., 42, 255-257.
Jamshidovich, A. S. (2024). NEUROPROTECTIVE EFFECT OF
CITICOLINE. EUROPEAN JOURNAL OF MODERN MEDICINE AND
PRACTICE, 4(1), 1-4.
Jamshidovich, A. S. (2024). THE ROLE OF TRIMETAZIDINE IN ISCHEMIC
CARDIOMYOPATHY. Journal of new century innovations, 44(2), 3-8.
Ачилов Шохрух Шавкиддин угли. (2024). ХИРУРГИЧЕСКИЕ МЕТОДЫ
ЛЕЧЕНИЯ АНЕВРИЗМЫ БРЮШНОЙ АОРТЫ . TADQIQOTLAR, 30(3), 120–
Ачилов Шохрух Шавкиддин угли (2023). ОСЛОЖНЕНИЯ ПОСЛЕ КОВИДА
НА СОСУДАХ НИЖНИХ КОНЕЧНОСТЕЙ. CENTRAL ASIAN JOURNAL
OF MEDICAL AND NATURAL SCIENCES Volume: 04 Issue: 06 Oct-Nov
ISSN:2660-4159, 400-403
Ачилов Шохрух Шавкиддин угли (2023). НАЛОЖЕНИЕ ШВОВ ПРИ
ГНОЙНЫХ ПРОЦЕССАХ НА ТКАНИ. CENTRAL ASIAN JOURNAL OF
MEDICAL AND NATURAL SCIENCES Volume: 04 Issue: 06 Oct-Nov
ISSN:2660-4159, 292-297
Khamroev, B. S. (2022). RESULTS OF TREATMENT OF PATIENTS WITH
BLEEDING OF THE STOMACH AND 12 DUO FROM NON-STEROIDAL
ANTI-INFLAMMATORY DRUGS-INDUCED OENP. Journal of
Pharmaceutical Negative Results, 1901-1910.
Nutfilloyevich, K. K. (2023). STUDY OF NORMAL MORPHOMETRIC
PARAMETERS OF THE LIVER. American Journal of Pediatric Medicine and
Health Sciences (2993-2149), 1(8), 302-305.
Nutfilloyevich, K. K. (2024). NORMAL MORPHOMETRIC PARAMETERS OF
THE LIVER OF LABORATORY RATS. ОБРАЗОВАНИЕ НАУКА И
ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 36(3), 104-113.
Nutfilloevich, K. K., & Akhrorovna, K. D. (2024). MORPHOLOGICAL
CHANGES IN THE LIVER IN NORMAL AND CHRONIC ALCOHOL
POISONING. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В
МИРЕ, 36(3), 77-85.
Kayumova, G. M., & Hamroyev, X. N. (2023). SIGNIFICANCE OF THE
FEMOFLOR TEST IN ASSESSING THE STATE OF VAGINAL
MICROBIOCENOSIS IN PRETERM VAGINAL DISCHARGE. International
Journal of Medical Sciences And Clinical Research, 3(02), 58-63.
Хамроев, Х. Н., & Тухсанова, Н. Э. (2022). НОВЫЙ ДЕНЬ В
МЕДИЦИНЕ. НОВЫЙ ДЕНЬ В МЕДИЦИНЕ Учредители: Бухарский
государственный медицинский институт, ООО" Новый день в медицине",
(1), 233-239.
Хамроев, Х. Н. (2024). Провести оценку морфологических изменений печени
в норме и особенностей характера ее изменений при хронической
алкогольной интоксикации. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ
ИДЕИ В МИРЕ, 36(3), 95-3.
Хамроев, Х. Н., & Туксанова, Н. Э. (2021). Сharacteristic of morphometric
parameters of internal organs in experimental chronic alcoholism. Тиббиётда янги
кун, 2, 34.
Хамроев, Х. Н., Хасанова, Д. А., Ганжиев, Ф. Х., & Мусоев, Т. Я. (2023).
Шошилинч тиббий ёрдам ташкил қилишнинг долзарб муаммолари:
Политравма ва ўткир юрак-қон томир касалликларида ёрдам кўрсатиш
масалалари. XVIII Республика илмий-амалий анжумани, 12.
Хамроев, Х. Н., & Хасанова, Д. А. (2023). Жигар морфометрик
кўрсаткичларининг меъёрда ва экспериментал сурункали алкоголизмда
қиёсий таснифи. Медицинский журнал Узбекистана| Medical journal of
Uzbekistan, 2.
Khamroyev, X. N. (2022). TOXIC LIVER DAMAGE IN ACUTE PHASE OF
ETHANOL INTOXICATION AND ITS EXPERIMENTAL CORRECTION
WITH CHELATE ZINC COMPOUND. European Journal of Modern Medicine
and Practice, 2(2), 12-16.
Xamroyev, X. N. (2022). The morphofunctional changes in internal organs during
alcohol intoxication. EUROPEAN JOURNAL OF MODERN MEDICINE AND
PRACTICE, 2(2), 9-11.
Khamroyev, X. N. (2022). TOXIC LIVER DAMAGE IN ACUTE PHASE OF
ETHANOL INTOXICATION AND ITS EXPERIMENTAL CORRECTION
WITH CHELATE ZINC COMPOUND. European Journal of Modern Medicine
and Practice, 2(2), 12-16.
Xamroyev, X. N. (2022). The morphofunctional changes in internal organs during
alcohol intoxication. EUROPEAN JOURNAL OF MODERN MEDICINE AND
PRACTICE, 2(2), 9-11.
Латипов, И. И., & Хамроев, Х. Н. (2023). Улучшение Резултат Диагностике
Ультразвуковой Допплерографии Синдрома Хронической Абдоминальной
Ишемии. Central Asian Journal of Medical and Natural Science, 4(4), 522-525.
Хамроев, Х. Н., & Уроков, Ш. Т. (2019). ВЛИЯНИЕ ДИФФУЗНЫХ
ЗАБОЛЕВАНИЙ ПЕЧЕНИ НА ТЕЧЕНИЕ И ПРОГНОЗ МЕХАНИЧЕСКОЙ
ЖЕЛТУХИ. Новый день в медицине, (3), 275-278.
Хамроев, Х. Н., & Ганжиев, Ф. Х. (2023). Динамика структурно-
функциональных нарушение печени крыс при экспериментальном
алгоколние циррозе. Рr oblemsofmodernsurgery, 6.
