SPECIFIC FEATURES OF THE EFFECT OF THE HEPARIN DRUG
Keywords:
Keywords: thrombocytopenia, anticoagulant, antithrombin, encephalopathyAbstract
Abstract. Heparin is a life-saving drug, which belongs to few clinically used
drugs without defined molecular structures in modern medicine. Heparin is the mostly
negatively charged biopolymer with a broad distributions in molecular weight, charge
density, and biological activities. Heparin is mainly composed of repeating trisulfated
disaccharide units, which is made by mast cells that are enriched in the intestines,
lungs or livers of animals. Porcine intestines and bovine lungs are two mostly used
sources for heparin isolation. Heparin is well known for its anticoagulant and
antithrombotic pharmacological effects. The anticoagulant activity of heparin is
attributable to a 3-O-sulfate and 6-O-sulfate containing pentasaccharide sequence or
a minimum eight-repeating disaccharide units containing the pentasaccharide
sequence that catalyzes the suicidal inactivation of factor Xa or thrombin by a serpin
or serine protease inhibitor named antithrombin III, respectively.
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