AUTOIMMUNE DISEASES: PATHOGENESIS AND THERAPEUTIC STRATEGIES
Ключевые слова:
Keywords: Autoimmune diseases, pathogenesis, therapeutic strategies, conventional therapies, biologics, targeted therapies, emerging therapies, challenges, future directions, personalized medicine, precision medicine, research, treatment resistance, side effects, interdisciplinary collaboration, innovation.Аннотация
Abstract: Autoimmune diseases pose significant challenges in both
understanding their complex pathogenesis and developing effective treatments. This
paper provides an overview of current therapeutic strategies, including conventional
therapies such as anti-inflammatory drugs and immunosuppressive agents, as well as
emerging approaches like biologics, targeted therapies, and cellular therapies.
Challenges in autoimmune disease management, such as treatment resistance, side
effects, and the need for personalized treatments, are discussed. The importance of
continued research efforts, interdisciplinary collaboration, and innovation in advancing
our understanding of autoimmune diseases and improving treatment outcomes is
emphasized. Looking ahead, the future landscape of autoimmune disease management
holds promise for more personalized, precise, and targeted approaches that optimize
treatment outcomes while minimizing side effects. Advances in genomics,
immunology, and therapeutic innovation are driving progress towards this goal, with
the ultimate aim of enhancing the quality of life for individuals living with autoimmune
diseases.
Библиографические ссылки
Bedard P. L. et al. Small molecules, big impact: 20 years of targeted therapy in
oncology //The Lancet. – 2020. – Т. 395. – №. 10229. – С. 1078-1088.
Bowness P. HLA-B27 //Annual review of immunology. – 2015. – Т. 33. – С. 29-
Chen B. et al. Predicting HLA class II antigen presentation through integrated deep
learning //Nature biotechnology. – 2019. – Т. 37. – №. 11. – С. 1332-1343.
Chowell D. et al. Patient HLA class I genotype influences cancer response to
checkpoint blockade immunotherapy //Science. – 2018. – Т. 359. – №. 6375. – С.
-587.
Choy E. H. et al. Translating IL-6 biology into effective treatments //Nature
Reviews Rheumatology. – 2020. – Т. 16. – №. 6. – С. 335-345.
DeWan A. T. Gene-gene and gene-environment interactions //Genetic
Epidemiology: Methods and Protocols. – 2018. – С. 89-110.
Dominguez-Villar M., Hafler D. A. Regulatory T cells in autoimmune disease
//Nature immunology. – 2018. – Т. 19. – №. 7. – С. 665-673.
Jiang F., Doudna J. A. CRISPR–Cas9 structures and mechanisms //Annual review
of biophysics. – 2017. – Т. 46. – С. 505-529.
Jörg S. et al. Environmental factors in autoimmune diseases and their role in
multiple sclerosis //Cellular and Molecular Life Sciences. – 2016. – Т. 73. – С.
-4622.
Keating S. T., El-Osta A. Epigenetics and metabolism //Circulation research. –
– Т. 116. – №. 4. – С. 715-736.
Lerner A., Jeremias P., Matthias T. The world incidence and prevalence of
autoimmune diseases is increasing //Int J Celiac Dis. – 2015. – Т. 3. – №. 4. – С.
-5.
Li P., Zheng Y., Chen X. Drugs for autoimmune inflammatory diseases: from small
molecule compounds to anti-TNF biologics //Frontiers in pharmacology. – 2017. –
Т. 8. – С. 460.
Picascia A. et al. Epigenetic control of autoimmune diseases: from bench to bedside
//Clinical immunology. – 2015. – Т. 157. – №. 1. – С. 1-15.
Pozzo D. et al. Tristetraprolin/ZFP36 Regulates the Turnover of Autoimmune-
Associated HLA-DQ mRNAs. – 2019.
Ramos P. S., Shedlock A. M., Langefeld C. D. Genetics of autoimmune diseases:
insights from population genetics //Journal of human genetics. – 2015. – Т. 60. –
№. 11. – С. 657-664.
Reindl‐Schwaighofer R. et al. Novel insights into non‐HLA alloimmunity in kidney
transplantation //Transplant International. – 2020. – Т. 33. – №. 1. – С. 5-17.
Rojas M. et al. Molecular mimicry and autoimmunity //Journal of autoimmunity. –
– Т. 95. – С. 100-123.
Rosser E. C., Mauri C. Regulatory B cells: origin, phenotype, and function
//Immunity. – 2015. – Т. 42. – №. 4. – С. 607-612.
Suurmond J. et al. Autoantibodies in systemic autoimmune diseases: specificity and
pathogenicity //The Journal of clinical investigation. – 2015. – Т. 125. – №. 6. – С.
-2202.
Uffelmann E. et al. Genome-wide association studies //Nature Reviews Methods
Primers. – 2021. – Т. 1. – №. 1. – С. 59.
Vinuesa C. G. et al. Follicular helper T cells //Annual review of immunology. –
– Т. 34. – С. 335-368.
Wang L., Wang F. S., Gershwin M. E. Human autoimmune diseases: a
comprehensive update //Journal of internal medicine. – 2015. – Т. 278. – №. 4. – С.
-395.
Wellington V. N. A. et al. Dietary supplementation with vitamin d, fish oil or
resveratrol modulates the gut microbiome in inflammatory bowel disease
//International Journal of Molecular Sciences. – 2021. – Т. 23. – №. 1. – С. 206.