PIRIMIDIN HALQASI ISHTIROKIDA SINTEZ VA PIRIMIDINNING BIOLOGIK FAOLLIGI
Keywords:
Kalit so’zlar: 6-metil-5-(piridin-4-ilsulfanil), 58b va 59a, 60 IC50 qiymatlari, folilpoli-γ-glutamat.Abstract
Anotatsiya: Hozirgi kunda molekulasida azot geteroatomi saqlagan geterosiklik
birikmalar qishloq xo’jaligi, tibbiyot va farmatsiyada keng qo’llaniladi. Ayniqsa pirrol,
pirimidin, pteridin, purin, turli xil azollar shular jumlasidandir. Bu sinf birikmalaridagi
azot geteroatomining molekulada joylashishiga qarab ular turli xil ko’pyoqlama
reaksion qobiliyatlarni namoyon qilishadi. Buning natijasida inson organizmidagi turli
xil fermentlar bilan bog’ hosil qilish kabi xususiyatlarni ko’rsatishadi.
Kondensirlangan pirrolopirimidin-4-on hosilalari molekulasida pirrol halqasidan
tashqari, pirimidin bo’lagida 1- va 3-holatdagi azot atomi, 4-uglerod atomidagi
karbonil guruhi (C=O), ularga tutashgan polimetilen zanjirida uglerod atomlari
mavjudligi sababli turfa xil reaksion markazlarga ega.
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