USE OF GLUCOCORTICOSTEROIDS IN PEDIATRIC PRACTICE

Аннотация

Soft dosage forms for external use (ointments, creams, gels, emulsions,
liniments, pastes) of anti-allergic action were studied according to regulatory
documentation and electronic resources in the field of health care. The possibilities of
their application in pediatric practice are investigated. Data on contraindications,
limitations and precautions according to the age of children are presented. The results
of the review are presented in the form of 4 tables containing information on trade and
nonproprietary (INN) names of medicinal products, pharmacological groups and age
restrictions. Nosebleeds are common not only in adults but also in children. The most
common causes of nasal bleeding in children are acute respiratory diseases and trauma.
The aim of the study was to investigate the nature of microflora isolated from the nose
in children with recurrent nosebleeds. Staphylococcus aureus was found to be the most
frequently isolated microflora in children of this clinical group. The author suggests
that the cause of recurrent nosebleeds may be stimulation of angiogenesis in the nasal
mucosa by carrying pathogenic microflora. NLRs are a consequence of the same
mechanisms that determine the activity of GCS. Upon interaction with the cell, GCS
diffuse or are transported into the cytoplasm where they interact with the type II
glucocorticoid receptor, which in the inactive state is bound to heat shock proteins
(HSPs) with molecular masses of 90 and 70Da. heat shock proteins (HSPs) with
molecular masses of 90 and 70 kDa.BTSPs contribute, on the one hand, to the
maintenance of the receptor's inactive state of the receptor in the absence of GCS, on
the other hand - to maintain its high affinity. After GCS is bound to the receptor, BTSH
is detached and the GCS-receptor complex migrates to the nucleus of the cell where it
interacts with the receptor. the cell nucleus, where it interacts with DNA regions
located in the promoter fragment of the steroid-responsive gene, the so-called
glucocorticoid response elements (GRE).
response element (GRE).